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Virology
(
a.k.a., Cell Biology 2)
Course Number:  110851
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biohazard sign

dr d
Ebola
"Just when you think your body is working fine, along comes a tiny virus that multiplies in you and your blood vessels disintegrate.
"

Last Update: 12 / 3 / 07
 
Trimester  2
2007-2008

Bergen County
Academies

with 
Dr. Don DeWitt
in room 227

 
2 classes / week: T & F
  3mods / class (mods 13-15)

Contact me at: 
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Virology Overview:
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Infectious disease is one of the few genuine adventures left in the world. 

The dragons are all dead and the lance grows rusty in the chimney corner... 
About the only sporting proposition that remains unimpaired by the relentless domestication of a once free-living human species is the war against those ferocious little fellow creatures, which lurk in dark corners and stalk us in the bodies of rats, mice and all kinds of domestic animals; which fly and crawl with the insects, and waylay us in our food and drink and even in our love.

- Hans Zinsser, Rats, Lice and History (1934) [courtesy Alison Jacobson]

borrowed from:
Dept.of Microbiology, University of Cape Town, South Africa


Introduction
 
The Cell Biology 1-3 sequence is a series of ELECTIVES for any student at Bergen County Academies who is seeking an in-depth exploration of the concept of the structure and function of genes (Cell Biology 1), and the application of molecular genetics to the study of viruses (Cell Biology 2) and immunology (Cell Biology 3).  These three courses are descendants of the coursework in the curriculum of Advanced Biology for senior AAST / AEDT students from 1995 - 2003.

Virology
 
As you may find out if you enroll in this elective, you can NOT truly understand how viruses infect and reproduce and therefore cause diseases if you do not understand how DNA and RNA work. Hence, coursework in genetics is a useful for Virology.

Resources

Although our textbook (Biology by Neil Campbell) has a chapter on viral and bacterial genetics (chapter 18) and a chapter on bacteria (chapter 27), the treatment of diseases is not a major focus. In addition, many of the viral diseases of interest are of recent concern due to major outbreaks in the last few years. In reality, there is little attention paid to infectious diseases in the textbook. However, the immunology resource in the textbook is chapter 43.  Even while we study viruses, you may wish to refer to this chapter occasionally. We will spend most of Cell Biology 3 there so anything you read now puts you ahead in the next course.

As we focus on viral diseases and the agents that cause them, we will rely heavily on three resources:

Outbreak

Outbreak the movie:
a role playing 
CDC or USAMRIID 
analysis and report

Video

The videotapes used are those that have been collected from the Discovery Channel, The Learning Channel, The Meaning of Life Series, and the hollywood film Outbreak. During the viewing of each video, we will employ a cooperative learning approach in which students are provided with a series of 50-60 questions about the video. Each student is assigned four or five questions. Thus, during the video, a student does not need to focus on every question, and can enjoythe show. However, in the following class period, each student presents their questions and answers to the class. Every student can then obtain all of the important information from the video. Each student then uses this information as background information for the Outbreak and Viral Infectious Disease research papers. 

Internet

A variety of references to virology resources can be found at the Virology  Internet References page.  These will be of great use in the research paper investigations.

Virology eText

In our study of viruses, students will use my computer based eText on Virology. This program is quite large (around 5Mb) and is now available for either the Macintosh or PC environment as 3 PDF files. This program may be downloaded from the Cell Bio 2 Download site.

Assessments
Current Events
Because virology is a hot area of biology and is changing daily, each student is required to maintain a portfolio of current events articles with one article due about every other week throughout the trimester. More detailed information can be found in the assessments webpage.

In-class Assessments
Although most students enrolled in Virology are self-motivated learners, demonstrable evaluation of information assimilated and processed is appropriate.  This will be seen as a cumulative in-class examination covering virology. More detailed information can be found in the assessments webpage.
Take-home Assessments
Take-home assignments include the Outbreak Project and the Infectious Disease research paper. More detailed information can be found by clicking on the assignment names or on the assessments webpage.


Special Note on HIV/AIDS

Although the causative agent for Acquired Immunodeficiency Syndrome (AIDS) is believed to be caused by Human Immunodeficiency Virus (HIV), we will split our study of AIDS into two components. 
  1. During Virology we will study the structure and replication process of HIV. 
  2. During Immunology we will gain insight into our defense mechanisms by investigating an example of the failure of the defense system, a resultant human species catastrophe and the evolutionary success story known as AIDS.



Student Objectives:
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Upon the successful completion of the course, the student will be able to describe:
1. the characteristics of VIRAL infection such as:

a. the structure of viruses

b. the processes in which viruses reproduce

c. how viruses are classified in terms of DNA or RNA

d. how viruses cause diseases and cancer

e. how viral infections are treated

f. the characteristics of the diseases caused by VIRUSES such as:


1) Herpes                                                                                                    


2) Hepatitis


3) Human Immunodeficiency Virus (HIV)


4) Human Papilloma Virus (HPV)


5) Influenza


6) Polio


7) Smallpox


8) Emerging viral diseases and the threat to human welfare



a) Dengue                                                                              



b) Ebola



c) Hanta



d) Lassa



e) Marburg



f) Motaba



g) West Nile Virus



h) Severe Acute Respiratory Syndrome Virus (SARS virus)

2. the ways in which viral infectious diseases may be used for bioterrorism
Ebola

interesting reading
about the first
outbreak of Ebola Zaire

by the husband of
actress Glenn Close.
We meet him in the video

the Plague Monkeys



Amazon.com
Reviews

Cobra Event

a great novel 
by the author 
of the Hot Zone
(see below)


Click below to go somewhere other than right here.
dr d
Dr. DeWitt
Websites
cellbiomap
Cell Bio.
Website Map
other pg
Cell Biology
Homepage
Biomap
Bio Dept
Electives SiteMap
 
 
 

up
Course Information
other pg
Formatting Rules For 
Written Submissions
up
Student objectives
other pg
Grading Policy
up
Assessments
other pg
Assignment due dates  (Tri 2)
other pg
Internet resources
down
Links to Interesting Books
other pg
Nobel Prize Winners 
for DeWitt Bio Courses
other pg
HANDOUTS (QuickAccess)
other pg
go to Cell Bio 1
other pg
go to Immunology (Cell Bio 3)

To obtain a black on white PRINTABLE version of this page, click PRINTABLE.