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Virology
Course Number:  110851
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This document can be found at: http://users.bergen.org/dondew/bio/cellbio/cellbio2PRINT.html
biohazard

the dreaded symbol
for biosafety hazards

Last update: 11 / 2 / 09

Trimester 2
2009-2010

Bergen County

Academies

with
Dr. Don DeWitt
in room 227

M & Th   mods 25-27

Contact me at:
dondew

outbreak
Outbreak the movie:
a role playing CDC analysis and report


Click below to go somewhere other than right here.
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Course Information Assessments (below)
Formatting Rules 
Student objectives Assignment due dates
Internet resources

Virology Overview:
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Infectious disease is one of the few genuine adventures left in the world. 
The dragons are all dead and the lance grows rusty in the chimney corner... 
About the only sporting proposition that remains unimpaired by the relentless domestication 
of a once free-living human species is the war against those ferocious little fellow creatures, 
which lurk in dark corners and stalk us in the bodies of rats, mice and all kinds of domestic animals; 
which fly and crawl with the insects, and waylay us in our food and drink and even in our love.


- Hans Zinsser, Rats, Lice and History (1934) [courtesy Alison Jacobson]

borrowed from:
Dept. of Microbiology, University of Cape Town, South Africa

Introduction
 
The Cell Biology 1-3 sequence is a series of ELECTIVES for any student at Bergen County Academies who is seeking an in-depth exploration of the concept of the structure and function of genes (Cell Biology 1), and the application of molecular genetics to the study of viruses (Cell Biology 2) and immunology (Cell Biology 3).  These three courses are descendants of the coursework in the curriculum of Advanced Biology for senior AAST / AEDT students from 1995 - 2003.
Resources

Although our textbook (Biology by Neil Campbell) has a chapter on viral and bacterial genetics (chapter 18) and a chapter on bacteria (chapter 27), the treatment of diseases is not a major focus. In addition, many of the viral diseases of interest are of recent concern due to major outbreaks in the last few years. In reality, there is little attention paid to infectious diseases in the textbook. However, the immunology resource in the textbook is chapter 43.  Even while we study viruses, you may wish to refer to this chapter occasionally. We will spend most of Cell Biology 3 there so anything you read now puts you ahead in the next course.

As we focus on viral diseases and the agents that cause them, we will rely heavily on three resources:

Video
The videotapes used are those that have been collected from the Discovery Channel, The Learning Channel, The Meaning of Life Series, and the hollywood film Outbreak. During the viewing of each video, we will employ a cooperative learning approach in which students are provided with a series of 50-60 questions about the video. Each student is assigned four or five questions. Thus, during the video, a student does not need to focus on every question, and can enjoy the show. However, in the following class period, each student presents their questions and answers to the class. Every student can then obtain all of the important information from the video. Each student then uses this information as background information for the Outbreak Project and the Viral Infectious Disease research paper.
Internet
A variety of references to virology resources can be found at the Virology Internet References page.  These will be of great use in the research paper investigations.
Virology eText
In our study of viruses, students will use my computer based eText on Virology. This program is quite large (around 5Mb) and is available for either the Macintosh or PC environment. This program along with its Persuasion Player program, must be downloaded from the Virology Download site.
Assessments
Current Events

Because virology is a hot area of biology and is changing daily, each student is required to maintain a portfolio of current events articles with one article due about every other week throughout the trimester. More detailed information can be found in the
assessments webpage.

In-class Assessments

Although most students enrolled in Cell Biology 2 are self-motivated learners, demonstrable evaluation of information assimilated and processed is appropriate.  This will be seen as a cumulative in-class examination covering Virology. More detailed information can be found in the assessments webpage.

Take-home Assessments

Take-home assignments include the Outbreak Project and the Infectious Disease research paper. More detailed information can be found by clicking on the assignment names or on the assessments webpage.

Special Note on HIV/AIDS

Although the causative agent for Acquired Immunodeficiency Syndrome (AIDS) is believed to be caused by Human Immunodeficiency Virus (HIV), we will split our study of AIDS into two components.
  1. During Virology we will study the structure and replication process of HIV.
  2. During Immunology (Cell Bio 3) while we study immunology we will gain insight into our defense mechanisms by investigating an example of the failure of the defense system, a resultant human species catastrophe and the evolutionary success story known as AIDS.


Student Objectives:
Assessments   Internet sites
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Upon the successful completion of the course, the student will be able to describe:
1. the characteristics of VIRAL infection such as:

a. the structure of viruses

b. the processes in which viruses reproduce

c. how viruses are classified in terms of DNA or RNA

d. how viruses cause diseases and cancer

e. how viral infections are treated

f. the characteristics of the diseases caused by VIRUSES such as:
1) Herpes



2) Hepatitis




Amazon.com Reviews

Cobra Event
an exciting novel
by the author 

of the Hot Zone (see below)

3) Human Immunodeficiency Virus (HIV)


4) Human Papilloma Virus (HPV)



5) Influenza


6) Polio  

7) Smallpox


8) Emerging viral diseases and the threat to human welfare
a) Dengue
b) Ebola
c) Hanta
d) Lassa
e) Marburg
f) Motaba
g) West Nile Virus



2. the ways in which viral infectious diseases may be used for bioterrorism

Student Assessments:
Internet sites
 
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During the study of virology, students will be given the opportunity to demonstrate their understanding of concepts via:
 
A.   Current Events Reviews bioterror

Five reviews of current events articles in an ongoing virology portfolio (17% of the final grade) will be submitted about various viruses and their impact.

1) Overview article: Emerging Infections from the Why Files (5%)
(This paper should be a minimum of 1 page and a maximum of 1.5 pages, using standard portfolio formatting rules.)

2) 1 influenza (3%)

3) 1 smallpox (3%)

4) 1 human papilloma virus (3%)

5) 1 bioterrorism using viruses (3%)



 B.   A Virology PPAO*     
* PPAO?  = Personal Performance Assessment Opportunity 
1) Topics:

Classification

Structure

Reproduction

Diseases / epidemiology

Treatment
2)  Resources: 

Ch. 18 (pg 328-340)

Dr. DeWitt's Virology program

Video: Understanding Viruses

Class notes (of course... the most accurate information)
3)  Assessment Style: Multiple Choice Exam + 6 pt Extra Credit Essay

Format: 20 questions: Type K format (Choose one letter: a-g)

a. Statement 1

b. Statement 2

c. Statement 3

d. Statement 4

e. None of the above, (or All of the above.)

f. a & b ---- or similar combo.

g. b, c & d---- or similar combo.

Date: Check on the Assignment Values & Due Dates website.

Value: 27% of your final grade

C.   In-depth Research Papers
1)   Research Paper: Infectious Disease
      - Topic is due on the date listed on the Due Dates website.
      - Paper is due on the date listed on the Due Dates website.
      - Value: 25% of the final grade
Topic Choices: (Choose ONE topic from the list below.)
V1
What are respiratory viral infections?  After discussing this question in general, pick ONE virus that causes respiratory infections and investigate it thoroughly in your paper.
V2
Herpesvirus infections cause a great deal of misery in our world.  Pick ONE strain of herpesvirus and investigate it thoroughly in your paper.
V3
Encephalitis infections can bring death quickly. Pick ONE strain of virus that causes encephalitis in humans or animals and investigate it thoroughly in your paper.
V4
Rabies is a disease that surrounds us in the nearby animal world.  What is the cause of this terrible disease?
V5
Egypt is not in North America but West Nile Virus is.  What is WNV and why should I worry about dead birds in my back yard?
V6
Hepatitis is inflammation of the liver.  How do viruses cause this condition?

V7
Smallpox disease has killed millions all over the world.  Its history also reflects and important part of the history of medicine.  What is smallpox and why is it a major concern by those who worry about bioterrorism?
 
2)   The Outbreak Project - due on the date listed on the Due Dates website.
- value: 25% of the final grade  (CLICK HERE for DETAILS)
D.  SPIRIT
As usual, 5% of your trimester grade is awarded in accordance with your spirit.
NOTE: Anyone caught cheating on ANY assignment will also receive a zero grade for their spirit grade for the trimester.  Of course, a zero grade will be given for the assignment as well.  No makeup options are available.

E.  END OF THE TRIMESTER
See listing on the Assignment Values & Due Dates website.
No assignments will be accepted after this date.

F. ADDITIONAL RESOURCES

1. Internet resources: These links are found on a separate website for easier access.

2. Other Interesting Books / Films: Please visit the books listing at: BOOKS

G.  LAST THOUGHT

Make sure you visit the main website at http://users.bergen.org/dondew/bio/cellbio/cellbio2.html, as there are often special goodies available.

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hotzone
basis for motaba 2
in Outbreak




 


 



 

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