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Immunology
1
Course
Number: 110861
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Stem Cells
"It will be fascinating to learn which genes are turned off permanently
when a stem cell differentiates from totipotent, to pluripotent to
multipotent."
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Trimester 2
2009-2010
Bergen
County
Academies
with
Dr.
Don DeWitt
in
room 227
2 classes / week: T & F
3
mods
/
class
(25-27)
Last
Update:
11
/ 23 / 09
Contact
me at:


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To obtain a black on
white PRINTABLE version of this page, click PRINTABLE.
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To obtain a black on
white PRINTABLE version of this page, click PRINTABLE.
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Introduction
The Cell
Biology 1-3 sequence is a series of ELECTIVES for any student at Bergen
County Academies who is
seeking an in-depth exploration of the concept of the structure and
function
of genes (Cell
Biology 1: [Currently not
running]),
and the application of molecular genetics to the study of viruses in Virology
(Cell
Biology 2) and Immunology 1 & 2. These three
courses are descendants of the coursework in the curriculum of Advanced
Biology for senior AAST / AEDT students from 1995 - 2003.
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Immunology 1 & 2
From
the day we are born to the day we die, microorganisms find us to be a
very desireable place to live and "raise their families". No matter
where you go on earth, you are going to encounter microscopic life
forms that may ignore you (hopefully) or try to take up residence
inside your cells someplace ... or every place in your body! With that
awareness, everyone should be curious about how our bodies have evolved
to battle the onslaught of microorganism infection.
Why Immunology 1 and 2?
Beginning in 2008-2009, my Immunology course has been divided into two
courses Immunology 1 and Immunology 2 which will be offered during
trimesters 2 and 3.
The reason for this division is the addition of an exploration of stem
cell biology in Immunology 1 which then has pushed the specific defense
system section of immunology into Immunology 2. I have added the
stem cell section to the course because of the importance of this topic
in today's society and because of the addition of our stem cell
associated research program at BCA (Biosciences
Research
Program). Please note that the major focus of stem
cell biology will be the understanding of how blood cell stem cells
differentiate into the cell types used by the human immune
system. It will NOT have a major focus on the pros and cons
regarding stem cell research. That approach would consume the
entire course. However, with the foundation provided by this
course in stem cell biology, further learning about stem cells will be
easier.
A forewarning:
Differentiation of cells from stem cells to the final functional cell
such as white blood cells is a genetic phenomenon as certain genes are
turned on, followed by either silencing or working in concert with
additional genes that become activated. You should be aware that
our discussions witll revolve around the workings of genes. If
you do not know what a gene is, then be prepared to do extra reading to
get caught up.
The question: "What is the difference between a gene, a genetic code
and a genome?" will echo though the room over and over again until I am
convinced you know the answer!
Your immune system works with two subsystems: the non-specific
subsystem and the specific subsystem.
- In Immunology 1 we explore the non-specific
immune
system and stem cell biology.
- In Immunology 2 we will spend
our time in this course
exploring in depth how your specific immune system works and at
the same time
explore the impact of the current world pandemic caused by HIV.
In doing so, we will spend considerable time reflecting on the early
years of the plague known as AIDS in order to understand how new and
immerging pathogens can take hold in our population often so
effectively that little can be done to stop it. In this
historical perspective we will view several important films including A Time of AIDS and And The Band Played On.
Resources
Although
our
textbook (Biology. 7th Edition, by
Neil Campbell) has a chapter on viral and bacterial genetics
(chapter18) and a few
pages on retroviruses with special attention to HIV the
treatment
of diseases such as AIDS is not a major focus. However, the immunology
resource in the textbook is
Chapter 43. Unfortunately, immunology is a very HOT topic in
biology and the chapter is already somewhat out of date As a
consequence an extensive set of lecture notes will be the major
resource for your understanding of immunology.
As we
focus
on immunology and AIDS, we will rely heavily
on three resources:
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How
Did
AIDS
Spread?
Time
Magazine:
Aug.
12, 1985
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Video
Videotapes
that
have
been collected from
PBS, the Discovery Channel, The Learning
Channel, The Meaning of Life Series, and the hollywood films A Time of AIDS
and And The Band Played On. Students are provided with a series of 30-60
questions
about the video depending on its length. Each student is assigned four
or five questions. Thus,
during the video, a student does not need to focus on every question,
and
can enjoythe show. However, in the following class period, each student
presents their questions and answers to the class. Every student can
then
obtain all of the important information from the video. Each student
then
uses this information as background information for The
Effects of AIDS on Human History
research
paper as well as the
two exams on immunology.
Internet
A variety
of references to immunology and AIDS resources can be found at the
Immunology 1 and 2 Internet
References page. These will be
of great use in the research paper investigations.
Virology eText
In Virology (Cell Biology 2) in
our
study of
viruses, students use my computer based eText on Virology. This
program is quite large (around 5Mb) and is available for either
the Macintosh or PC environment.
This program along with its Persuasion Player program, must be
downloaded
from a loaned CD. In Immunology, it will be essential for those
who have not studied
viruses to do so through this program. In addition, information
about HIV is available for those who need a review.
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Current
Events
Because immunology and AIDS is a hot
area of biology and is changing daily, each
student
is required to maintain a portfolio of current events
articles with one article due about every other week throughout the
trimester. More detailed
information can be found in the assignments
section below.
In-class Assessments
Although
most students enrolled in Immunology are self-motivated learners
demonstrable evaluation of information assimilated and processed is
appropriate. This will be seen as a two in-class
examinations
covering Immunology. More detailed information can be found in the assignments
section below.
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To obtain a black on
white PRINTABLE version of this page, click PRINTABLE.
To
view the course outline: OUTLINE
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To obtain a black on
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To
aid in the loading of this webpage, I have moved the Assignments for Immunology 1 to a separate page. Click below to view the
assignments.
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