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Immunology 1
Course Number:  110861
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stem cells
dr d
Stem Cells
"It will be fascinating to learn which genes are turned off permanently when a stem cell differentiates from totipotent, to pluripotent to multipotent."

 
Trimester 2
2009-10

Bergen County
Academies

with 
Dr. Don DeWitt
in room 227

2 classes / week: T & F
3 mods / class (25-27)

Last Update: 11 / 2 / 09

Contact me at: 
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Immunology
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Introduction
 
The Cell Biology 1-3 sequence is a series of ELECTIVES for any student at Bergen County Academies who is seeking an in-depth exploration of the concept of the structure and function of genes (Cell Biology 1:  [Currently not running]), and the application of molecular genetics to the study of viruses in Virology (Cell Biology 2) and Immunology 1 & 2.  These three courses are descendants of the coursework in the curriculum of Advanced Biology for senior AAST / AEDT students from 1995 - 2003. After completion of Cell Biology 1, in addition to, or instead of Cell Biology 2 and 3, a student may wish to enroll in the related courses: Genetics or Microbiology.

Immunology 1 & 2
 
From the day we are born to the day we die, microorganisms find us to be a very desireable place to live and "raise their families". No matter where you go on earth, you are going to encounter microscopic life forms that may ignore you (hopefully) or try to take up residence inside your cells someplace ... or every place in your body! With that awareness, everyone should be curious about how our bodies have evolved to battle the onslaught of microorganism infection. 

Why Immunology 1 and 2?

Beginning in 2008-2009, my Immunology course has been divided into two courses Immunology 1 and Immunology 2 which will be offered during trimesters 1 and 2. 

The reason for this division is the addition of an exploration of stem cell biology in Immunology 1 which then has pushed the specific defense system section of immunology into Immunology 2.  I have added the stem cell section to the course because of the importance of this topic in today's society and because of the addition of our stem cell associated research program at BCA (Biosciences Research Program).  Please note that the major focus of stem cell biology will be the understanding of how blood cell stem cells differentiate into the cell types used by the human immune system.  It will NOT have a major focus on the pros and cons regarding stem cell research.  That approach would consume the entire course.  However, with the foundation provided by this course in stem cell biology, further learning about stem cells will be easier.


A forewarning:

Differentiation of cells from stem cells to the final functional cell such as white blood cells is a genetic phenomenon as certain genes are turned on, followed by either silencing or working in concert with additional genes that become activated.  You should be aware that our discussions witll revolve around the workings of genes.  If you do not know what a gene is, then be prepared to do extra reading to get caught up.

The question: "What is the difference between a gene, a genetic code and a genome?" will echo though the room over and over again until I am convinced you know the answer!


Your immune system works with two subsystems: the non-specific subsystem and the specific
subsystem.
  • In Immunology 1 we explore the non-specific immune system and stem cell biology. 
  • In Immunology 2 we will spend our time in this course exploring in depth how your specific immune system works and at the same time explore the impact of the current world pandemic caused by HIV.  In doing so, we will spend considerable time reflecting on the early years of the plague known as AIDS in order to understand how new and immerging pathogens can take hold in our population often so effectively that little can be done to stop it.  In this historical perspective we will view several important films including A Time of AIDS and And The Band Played On.

Resources

Although our textbook (Biology. 7th Edition, by Neil Campbell) has a chapter on viral and bacterial genetics (chapter18) and a few pages on retroviruses with special attention to HIV the treatment of diseases such as AIDS is not a major focus. However, the immunology resource in the textbook is Chapter 43. Unfortunately, immunology is a very HOT topic in biology and the chapter is already somewhat out of date  As a consequence an extensive set of lecture notes will be the major resource for your understanding of immunology.

As we focus on immunology and AIDS, we will rely heavily on three resources:

Time 1985
How Did AIDS Spread?
Time Magazine:
Aug. 12, 1985


Video

Videotapes that have been collected from PBS, the Discovery Channel, The Learning Channel, The Meaning of Life Series, and the hollywood films A Time of AIDS and And The Band Played On.  Students are provided with a series of 30-60 questions about the video depending on its length. Each student is assigned four or five questions. Thus, during the video, a student does not need to focus on every question, and can enjoythe show. However, in the following class period, each student presents their questions and answers to the class. Every student can then obtain all of the important information from the video. Each student then uses this information as background information for The Effects of AIDS on Human History research paper as well as the two exams on immunology.

Internet

A variety of references to immunology and AIDS resources can be found at the Immunology Internet References page.  These will be of great use in the research paper investigations.

Virology eText

In Virology (Cell Biology 2) in our study of viruses, students use my computer based eText on Virology.This program is quite large (around 5Mb) and is available for either the Macintosh or PC environment. This program along with its Persuasion Player program, must be downloaded from a loaned CD.  In Immunology, it will be essential for those who have not studied viruses to do so through this program.  In addition, information about HIV is available for those who need a review.

Current Events

Because immunology and AIDS is a hot area of biology and is changing daily, each student is required to maintain a portfolio of current events articles with one article due about every other week throughout the trimester. More detailed information can be found in the assignments section below.

In-class Assessments

Although most students enrolled in Immunology are self-motivated learners demonstrable evaluation of information assimilated and processed is appropriate.  This will be seen as a two in-class examinations covering Immunology. More detailed information can be found in the assignments section below.
























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