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Antibodies
"If some pathogen came along that could shut down the production
of antibodies, we would be in for many nasty plagues!"
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Trimester 3
2009-10
Bergen
County
Academies
with
Dr.
Don DeWitt
in
room 227
2
classes / week: T & F
3 mods / class
(mods 25-27)
Last
Update: 3 / 19 / 10
Contact
me
at:

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To obtain a black on
white PRINTABLE version of this page, click PRINTABLE.
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Introduction
The Cell
Biology 1-3 sequence is a series of ELECTIVES for any student at Bergen
County Academies who is
seeking:
- an in-depth exploration of
the concept of the structure and
function
of genes (Cell
Biology 1: [a.k.a, Molecular
Genetics (Currently not
running)]),
and
- the application of molecular
genetics to the study of viruses in Virology
(a.k.a., old Cell
Biology 2) which runs during
trimester 2 and 3.) and
- Immunology
1 (a.k.a., Cell Biology 3) & Immunology 2.
These
three
(four) courses are descendants of the coursework in the curriculum of
Advanced
Biology for senior AAST / AEDT students from 1995 - 2003. PLEASE
NOTE: In
order to enroll in Immunology 2 a student should have taken some other
course from me such as Anatomy and Physiology, Immunology, Molecular
Biology,
Physiological Control Systems or Virology.
In addition, it would be wise to bone up on what a gene is and how they
work. Immunology I's material will be provided as a handout in
Immunology II as homework if you did not take Immunology I.
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Immunology I & II
From
the day we are born to the day we die, microorganisms find us to be a
very desireable place to live and "raise their families". No matter
where you go on earth, you are going to encounter microscopic life
forms that may ignore you (hopefully) or try to take up residence
inside your cells someplace ... or every place in your body! With that
awareness, everyone should be curious about how our bodies have evolved
to battle the onslaught of microorganism infection.
Why Immunology I and II?
Beginning in 2007-2008, my Immunology course has been divided into two
courses Immunology I and Immunology II which will be offered during
trimesters 2 and 3, respectively.
The reason for this division is the addition of an exploration of stem
cell biology in Immunology I which then has pushed the specific defense
system section of immunology into Immunology II. I have added the
stem cell section to the course because of the importance of this topic
in today's society and because of the addition of our stem cell
associated research program at BCA (Biosciences
Research
Program).
Hence we are ready to focus on HOW
our bodies protect us from the constant onslaught of microbial
pathogens of the viral, bacterial, fungal or plasmodial type. I
have suggested that you study molecular genetics before we tackle
immunology II because you will soon find out that the production of
antibodies as well as other key immunological structures such as Human
Leukocyte Antigens (HLA) are far easier understood if you understand
how
genes work. In addition, awareness of at least one class of
pathogen in terms of their structure, life cycle and diseases they
cause will enable you to appreciate how effective your immune system is.
With
that background in mind, we will spend our time in this course
exploring in depth how your immune system works and at the same time
explore the impact of the current world pandemic caused by HIV.
In doing so, we will spend considerable time reflecting on the early
years of the plague known as AIDS in order to understand how new and
immerging pathogens can take hold in our population often so
effectively that little can be done to stop it. In this
historical perspective we will view several important films including A Time of AIDS and And The Band Played On.
Resources
Although
our
textbook (Biology by
Neil Campbell) has a chapter on viral genetics (Chapter 17) and a few
pages on retroviruses with special attention to HIV the
treatment
of diseases such as AIDS is not a major focus. However, the immunology
resource in the textbook is
Chapter 39. Unfortunately, immunology is a very HOT topic in
biology and the chapter is already somewhat out of date. As a
consequence and extensive set of lecture notes will be the major
resource for your understanding of immunology.
As we
focus
on immunology and AIDS, we will rely heavily
on three resources:
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How
Did AIDS Spread?
Time
Magazine:
Aug.
12, 1985
What
Has Been
the
Impact
of
AIDS on
Human
History?
Time
Magazine:
Feb.
12, 2001
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Video
Videotapes
that have been collected from
PBS, the Discovery Channel, The Learning
Channel, The Meaning of Life Series, and the hollywood films A Time of AIDS
and And The Band Played On. Students are
provided with a series of 30-60
questions
about the video depending on its length. Each student is assigned four
or five questions. Thus,
during the video, a student does not need to focus on every question,
and
can enjoythe show. However, in the following class period, each student
presents their questions and answers to the class. Every student can
then
obtain all of the important information from the video. Each student
then
uses this information as background information for The
Effects of AIDS on Human History
and the My Favorite Non-viral Infection
research papers.
Internet
A variety
of references to immunology and AIDS resources can be found at the Internet
References page. These will be
of great use in the research paper investigations.
Virology eText
In Virology (Cell Biology 2) in
our
study of
viruses, students use my computer based eText on Virology.This
program is quite large (around 5Mb) and is available for either
the Macintosh or PC environment.
This program along with its Persuasion Player program, must be
downloaded
from a loaned CD. In Immunology, it will be essential for those
who have not studied
viruses to do so through this program. In addition, information
about HIV is available for those who need a review.
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Current
Events
Because immunology and AIDS is a hot
area of biology and is changing daily, each
student
is required to maintain a portfolio of current events
articles with one article due about every other week throughout the
trimester. More detailed
information can be found in the assignments website.
In-class
Assessments
Although
most students enrolled in Immunology are self-motivated learners
demonstrable evaluation of information assimilated and processed is
appropriate. This will be seen as a two in-class
examinations
covering Immunology. More detailed information can be found in the assignments website.
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To obtain a black on
white PRINTABLE version of this page, click PRINTABLE.
Upon
the successful completion of the course, the student will be able to
describe:
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the
ways in which the human body defends itself from infection including: |
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a. |
the
difference between nonspecific and specific defense mechanisms |
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b. |
the role of
specialized cells in the immune system |
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c. |
the
function
of antigens and antibodies |
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d. |
the
difference
between active and passive immunity |
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e. |
how
allergic
reactions are generated |
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2.
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the
ways in which HIV defeats the human immune system including:
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the mode of
infection
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b. |
the time
course of infection and the symptoms of
infection
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c. |
the
development of AIDS
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d. |
the
history of
the outbreak and resultant pandemic
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To
aid in the loading of this webpage, I have moved the Assignments for Immunology to a separate page. Click below to view the
assignments.
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