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Immunology 2
Course Number:  ??????
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Ab

dr d
Antibodies
"If  some pathogen came along that could shut down the production of antibodies, we would be in for many nasty plagues!"

 
Trimester 3
2009-10

Bergen County
Academies

with 
Dr. Don DeWitt
in room 227

2 classes / week: T & F
3 mods / class (mods 25-27)

Last Update: 10 / 19 / 09

Contact me at: 
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Immunology 2
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Introduction
 
The Cell Biology 1-3 sequence is a series of ELECTIVES for any student at Bergen County Academies who is seeking:
  1. an in-depth exploration of the concept of the structure and function of genes (Cell Biology 1:  [a.k.a, Molecular Genetics (Currently not running)]), and
  2. the application of molecular genetics to the study of viruses in Virology (a.k.a., Cell Biology 2) which maybe will run as a Project in trimester 2.) and
  3. Immunology 1 (a.k.a., Cell Biology 3) & Immunology 2
These three (four) courses are descendants of the coursework in the curriculum of Advanced Biology for senior AAST / AEDT students from 1995 - 2003. PLEASE NOTE:  In order to enroll in Immunology 2 a student should have taken some other course from me such as Anatomy and Physiology, Immunology, Molecular Biology, Physiological Control Systems or Virology.  In addition, it would be wise to bone up on what a gene is and how they work.  Immunology 1's material will be provided as a handout in Immunology 2 as homework.

Immunology 1 & 2
 
From the day we are born to the day we die, microorganisms find us to be a very desireable place to live and "raise their families". No matter where you go on earth, you are going to encounter microscopic life forms that may ignore you (hopefully) or try to take up residence inside your cells someplace ... or every place in your body! With that awareness, everyone should be curious about how our bodies have evolved to battle the onslaught of microorganism infection. 

Why Immunology 1 and 2?

Beginning in 2007-2008, my Immunology course has been divided into two courses Immunology 1 and Immunology 2 which will be offered during trimesters 3 and 1, respectively. 

The reason for this division is the addition of an exploration of stem cell biology in Immunology 1 which then has pushed the specific defense system section of immunology into Immunology 2.  I have added the stem cell section to the course because of the importance of this topic in today's society and because of the addition of our stem cell associated research program at BCA (Biosciences Research Program).

Hence we are ready to focus on HOW our bodies protect us from the constant onslaught of microbial pathogens of the viral, bacterial, fungal or plasmodial type.  I have suggested that you study molecular genetics before we tackle immunology because you will soon find out that the production of antibodies as well as other key immunological structures such as Human Leukocyte Antigens (HLA) are far easier understood if you understand how genes work.  In addition, awareness of at least one class of pathogen in terms of their structure, life cycle and diseases they cause will enable you to appreciate how effective your immune system is.


With that background in mind, we will spend our time in this course exploring in depth how your immune system works and at the same time explore the impact of the current world pandemic caused by HIV.  In doing so, we will spend considerable time reflecting on the early years of the plague known as AIDS in order to understand how new and immerging pathogens can take hold in our population often so effectively that little can be done to stop it.  In this historical perspective we will view several important films including A Time of AIDS and And The Band Played On.

Resources

Although our textbook (Biology by Neil Campbell) has a chapter on viral genetics (Chapter 17) and a few pages on retroviruses with special attention to HIV the treatment of diseases such as AIDS is not a major focus. However, the immunology resource in the textbook is Chapter 39.  Unfortunately, immunology is a very HOT topic in biology and the chapter is already somewhat out of date.  As a consequence and extensive set of lecture notes will be the major resource for your understanding of immunology.

As we focus on immunology and AIDS, we will rely heavily on three resources:

Time 1985
How Did AIDS Spread?
Time Magazine:
Aug. 12, 1985

Time 2001
What Has Been
the Impact
of AIDS on
Human History?
Time Magazine:
Feb. 12, 2001

Video

Videotapes that have been collected from PBS, the Discovery Channel, The Learning Channel, The Meaning of Life Series, and the hollywood films A Time of AIDS and And The Band Played On.  Students are provided with a series of 30-60 questions about the video depending on its length. Each student is assigned four or five questions. Thus, during the video, a student does not need to focus on every question, and can enjoythe show. However, in the following class period, each student presents their questions and answers to the class. Every student can then obtain all of the important information from the video. Each student then uses this information as background information for The Effects of AIDS on Human History research paper as well as the two exams on immunology.

Internet

A variety of references to immunology and AIDS resources can be found at the Internet References page.  These will be of great use in the research paper investigations.

Virology eText

In Virology (Cell Biology 2) in our study of viruses, students use my computer based eText on Virology.This program is quite large (around 5Mb) and is available for either the Macintosh or PC environment. This program along with its Persuasion Player program, must be downloaded from a loaned CD.  In Immunology, it will be essential for those who have not studied viruses to do so through this program.  In addition, information about HIV is available for those who need a review.

Current Events

Because immunology and AIDS is a hot area of biology and is changing daily, each student is required to maintain a portfolio of current events articles with one article due about every other week throughout the trimester. More detailed information can be found in the assignments website.

In-class Assessments

Although most students enrolled in Immunology are self-motivated learners demonstrable evaluation of information assimilated and processed is appropriate.  This will be seen as a two in-class examinations covering Immunology. More detailed information can be found in the assignments website.






















 







Student Objectives:
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Upon the successful completion of the course, the student will be able to describe:
1. the ways in which the human body defends itself from infection including:

a. the difference between nonspecific and specific defense mechanisms



b. the role of specialized cells in the immune system



c. the function of antigens and antibodies



d. the difference between active and passive immunity



e. how allergic reactions are generated


2.
the ways in which HIV defeats the human immune system including:

a. the mode of infection




b. the time course of infection and the symptoms of infection




c. the development of AIDS




d. the history of the outbreak and resultant pandemic























Student Assessments:


To aid in the loading of this webpage, I have moved the Assignments for Immunology to a separate page. Click below to view the assignments.

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