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Nucleotides
Molecular Biology 5 with Dr. Don DeWitt (v1 as of  1 / 11 / 06)

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Building Blocks of Nucleic Acids


Nucleic acids such as RNA and DNA are polymers made from the monomer building blocks called nucleotides, which are made up of a base (5 kinds) + a sugar (2 kinds) + a phosphate. To be completely correct, nucleic acids are polymers of monophosphate nucleotides.  They are connected via a condensation reaction which creates a phosphodiester bond between sugars. (See Page 3

Other nucleotides are known that have more than one phosphate (e.g. adenosine triphosphate (ATP) which has three phosphates attached.)
 
Bases
(Purines and Pyrimidines)
Nucleosides
(Base + Sugar)
Nucleotides
(Base + Sugar + Phosphate )

Purines
have
two rings
Pyrimidines
have
one ring

adenine (A)
(DNA/RNA)

guanine (G)
(DNA/RNA)


cytosine (C)
(DNA/RNA)

thymine  (T)
(DNA only)

uracil (U)
(RNA only)

See structures Page 2.

Sugar is
Ribose
(used in RNA)
Sugar is
Deoxyribose
(used in DNA)

adenosine deoxyadenosine
guanosine deoxyguanosine
cytidine deoxycytidine

deoxythymidine
uridine

These molecules are not very
important in nucleic acid chemistry
but show how the nucleotides get
their names.

Sugar is
Ribose
(used in RNA)
Sugar is
Deoxyribose
(used in DNA)

adenosine
monophosphate
(AMP)
deoxyadenosine
monophosphate
(dAMP)
guanosine
monophosphate
(GMP)
deoxyguanosine
monophosphate
(dGMP)
cytidine
monophosphate
(CMP)
deoxycytidine
monophosphate
(dCMP)
T not used
in RNA
deoxythymidine
monophosphate
(dTMP)
uridine
monophosphate
(UMP)
U not used
in DNA

See structures Page 3.


Abbreviations and Symbols for Nucleic Acids, Polynucleotides and their Constituents


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